Lecture 19 - Smooth Muscle Contraction Bio416K Spring 2010

Lecture 19 - Smooth Muscle Contraction Bio416K Spring 2010...

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Unformatted text preview: Smooth Muscle Inner circular layer Outer longitudinal Peristalsis and Segmentation Peristalsis Segmentation Smooth Muscle is Specialized Many different types (vascular, gastrointestinal, urinary, respiratory, reproductive, and ocular) Controlled by neurotransmitters, hormones, neurohormones and paracrines Smooth muscle cells must act as integrating centers Lack specialized neuromuscular junctions ANS variscosities Contractile filaments arranged in oblique bundles Variable electrical properties unstable membrane potentials Smooth Muscle is Specialized No myofibrils composed of sarcomeres No transverse (T)-tubules, no terminal cisternae = no triad Poorly developed sarcoplasmic reticulum (SR) Ca 2+ signal from SR and extracellular fluid Myosin-linked regulatory process Slow speed of contraction Can undergo mitosis and proliferate (hyperplasia) Smooth Muscle Contracts and relaxes more slowly Uses less energy to generate force Maintains force for long periods Low oxygen consumption, fatigue resistant Smooth Muscle is Single-unit or Multi-unit controlled by neurotransmitters, hormones, neurohormones and paracrines Pacemaker cell? Neurotransmitter Release at a Varicosity of an Autonomic Neuron...
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Lecture 19 - Smooth Muscle Contraction Bio416K Spring 2010...

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