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Lecture 21 - Muscle Energetics and Fiber Types Bio416K Spring 2010

Lecture 21 - Muscle Energetics and Fiber Types Bio416K Spring 2010

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ATP needed for: 1. Cross-bridge cycling (myosin ATPase) 2. During relaxation to pump Ca 2+ back into sarcoplasmic reticulum (Ca 2+ -ATPase) 3. Maintenance of resting membrane potential (Na + -K + -ATPase) Muscle Energy Needs for ATP + energy ATPase
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ATP (continued) 1. Only energy source used directly for muscle contraction 2. ATP stores consumed within a few seconds of muscle activity 3. ATP must be regenerated as fast as it is broken down 4. ATP regenerated by three pathways Muscle Energy Needs for ATP + energy ATPase
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CP Creatine ADP ATP GLUCOSE Glycolysis Pyruvic acid Lactic acid ATP 2 O 2 GLUCOSE Pyruvic acid ATP 36 O 2 Fatty acids 1) Direct phosphorylation 2) Anaerobic mechanism - 3) Aerobic mechanism - (glycolytic) (oxidative) Methods (Pathways) Generating ATP During Muscle Activity 5-15 seconds 30-60 seconds Many hours CK
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0 40 20 80 60 100 Time (msec) Single stimulus Extrinsic eye muscle (fast twitch-glycolytic) Type IIb Gastrocnemius muscle (fast twitch-oxidative/glycolytic)
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Unformatted text preview: Type IIa Soleus muscle (slow twitch-oxidative) Type I Twitch Response Times of Different Muscle Types Muscle Fiber Types * Tissues stained for mitochondria and mitochondrial enzymes Fast-twitch Glycolytic and Slow-twitch Oxidative Muscle Fibers Structural and Functional Characteristics of Muscle Fiber Types Myoglobin content High High Low Glycogen stores Low Intermediate High Motor Units Forearm 1, Increasing clench force Forearm 1, Continued clench at maximum forc 0.00 4.00 8.00 12.00 16.00 20.00 24.00 28.00 32.00 36.00 40.00 44.00 48.00 52.00 56.00 60.00 64.00 68.00 72.00 76.00 80.00 84.00 88.00 92.00 96.00 100.00 104.00 108.00 112.00 116.00 seconds 0.00 10.00 20.00 30.00 40.00 Kg Force-4.00 0.00 4.00 mV EMG 0.00 0.40 0.80 1.20 1.60 mV-sec Integrated EMG EMG-2 Lab Data State of Muscle Fatigue Location and Possible Causes of Muscle Fatigue...
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