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a and p case study

a and p case study - 1..Explain , .First,hissymptoms,...

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1. What is the most likely diagnosis of the condition described. Explain. Melanoma is the most likely diagnosis for that patient, and it is the most dangerous form of skin cancer  which develops in melanocytes that produce melanin. First, his symptoms, such as a growth on the skin  including darkly pigmented spot due to increased level of melanin production, which is surrounded by a  halo of inflamed skin and tumor malignancy, put him at high risk of having melanoma. Second, he  undergoes frequent UV exposure and it is an important stimulus to genetic changes in genes which  regulate cell division and tissue growth. Third, he is a Caucasian with a very fair complexion, numerous  freckles and blond hair.Thus, melanin produced in response to melanocyte stimulating hormone, is broken  down rapidly by enzyme from the keratinocytes that increases his chance of getting disease 20 times  more likely than African Americans.  2. Describe the normal histology of the epidermis which relates to this condition. The epidermis consists of a few layers including stratum corneum, stratum granulosum, stratum spinosum  and stratum basale or stratum germinativum. In the stratum basale cells actively divided by mitosis to  replace cells which exfoliated from skin’s surface. The new formed cells push up into upper layers and 
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  • Spring '10
  • hago
  • Stratum Corneum, Melanocyte Stimulating Hormone, stratum basale cells, stratum spinosum cells, darkly pigmented spot

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