Lecture_14_3-9-10-PDF_41128

Lecture_14_3-9-10-PDF_41128 - Lipid Metabolism(Lec 14-17...

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1.Lipid digestion, Absorption, and transport A. Digestion and Adsorption B. Lipid transport 2. Fatty acid oxidation A. Fatty acid activation B. Transport across the mitochondrial membrane C. b -oxidation D. Oxidation of unsaturated Fatty Acids E. Oxidation of odd-chain fatty acids Lipid Metabolism (Lec 14-17) Lec14
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3. Ketone bodies 4. Fatty Acid Biosynthesis A. Transport of mt acetyl-CoA into the cytosol B. Aceyl-CoA Carboxylase C. Fatty acid synthase D. Elongases and Desaturases E. Synthesis of Triglycerols Lec15 Lipid Metabolism (Lec 14-17)
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5. Regulation of Fatty acid metabolism 6. Synthesis of other lipids A. Glycerophospholipids B. Sphingolipids C. Prostaglandins 7. Cholesterol Metabolism A. Cholesterol biosynthesis B. Regulation of Cholesterol Synthesis C. Cholesterol Transport and Atherosclerosis Lipid Metabolism (Lec 14-17) Lec16 Lec17
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The major function of lipids •Forming a barrier to the extracellular environment •Maintaining membrane fluidity •Serving as an energy store In hibernating mammals, fat reserves are synthesized during the warmer months and are oxidized during the winter to keep animal alive.
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Lec 1-13 Lec 14-17
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Summary of lipid metabolism
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As indicated by the pointer, note the peripheral displacement of the nucleus of the fat cell by the globule of lipid material. Adipose tissue Fat cell (Adipocyte)
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Triacylglycerols (AKA, fats or triglycerides) Constitute ~90% dietary lipid and are the major form of metabolic energy storage in humans Lec-5 (lipids)
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Summary of lipid metabolism
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Fats are water insoluble Whereas digestive enzymes (lipases) are How does this work?
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A. Digestion and absorption Fats need to be “solubilized” in the intestine and bile acids (AKA, bile salts) act as detergents to do this. Bile acids are a derivative of and are organic acids. p254 bile acid
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Role of Bile Acids in Fat Digestion and Absorption are derivatives of synthesized in the hepatocyte. Bile acids are facial , that is, they contain both hydrophobic ( lipid soluble ) and hydrophilic ( water soluble ) faces.
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1. Emulsification of lipid aggregates : Bile acids have detergent action on particles of dietary fat which causes fat globules to break down or be emulsified into minute, microscopic droplets. Emulsification is not digestion per se, but is of importance because it greatly increases the surface area of fat, making it available for digestion by lipases , which cannot access the inside of lipid droplets. 2. Solubilization and transport of lipids in an aqueous environment : Bile acids are lipid carriers and are able to solubilize many lipids by forming micelles - aggregates of lipids such as fatty acids, cholesterol and monoglycerides - that remain suspended in water. Their amphipathic nature enables bile acids to carry out two important functions:
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Lipids are digested at the membrane aqueous interface.
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This note was uploaded on 09/15/2010 for the course BCHS 3305 taught by Professor Fujita during the Spring '10 term at University of Houston.

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Lecture_14_3-9-10-PDF_41128 - Lipid Metabolism(Lec 14-17...

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