Lecture_17_3-30-10-PDF_41479

Lecture_17_3-30-10-PDF_41479 - review Lec16 5. Regulation...

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5. Regulation of Fatty acid metabolism 6. Synthesis of other lipids A. Glycerophospholipids B. Sphingolipids C. Prostaglandins Lec16 review
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Fatty acids are the precursors not just of TAGs but of membrane lipids and certain signaling molecules Glycerophospholipids Sphingolipids Prostaglandins review
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We are here Summary of lipid metabolism review
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Membrane lipids Glycerolipids and sphingolipids review
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Lec-5 review
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Biosynthesis of PE, PC, and PS PE PC PS review
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Biosynthesis of PE and PC PE and PC synthesis requires the formation of a CDP-ethanolamine or a CDP-choline intermediate. ( PE ) ( PC ) CDP: cytidine diphosphate review
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Biosynthesis of PE and PC ( PE ) ( PC ) Phosphorylation of choline to phosphocholine followed by adduction to CTP forming the CDP-choline derivative. This finally reacts with 1,2 diacyl glycerol to form the appropriate phospholipid. review
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Plasmalogen protects cells against the damaging effects of singlet oxygen (p716) In many tissues plasmalogens are minor constituents, but in heart tissue nearly 50% and Nervous tissues, testes and kidneys also contain significant amounts (~20%) of plasmalogens. review
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Summary Triacylglycerol (TAG) precursors are used to synthesize glycerophospholipids review
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7. Cholesterol Metabolism A. Cholesterol biosynthesis B. Regulation of Cholesterol Synthesis C. Cholesterol Transport and Atherosclerosis Lipid Metabolism Lec17
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We are here Summary of lipid metabolism
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Fig. 9-10 (p254)
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Cholesterol Enhance the permeability-barrier properties of the lipid bilayer Cholesterol
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The structure of cholesterol Cholesterol in a lipid bilayer
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Temperature with cholesterol without cholesterol Cholesterol makes phospholipid membranes
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Functional roles of cholesterol 1. Essential component of animal cell membranes. 2. Precursor of hormones and 3. Precursor of 4. Not required in the human diet because our cells can synthesize cholesterol de novo.
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Cholesterol biosynthesis Location of pathway Most cells can make cholesterol, but is most active. The pathway is located in the , beginning with The process has four major steps (student companion, p241-38) 1. Condensation of 3 acetyl-CoA units to mevalonate 2. Conversion of mevalonate into activated isoprene 3. Polymerization of six 5-carbon isoprene units (30 carbons) to form squalene 4. Cyclization of squalene to create the steroid nucleus
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Cholesterol Synthesis: Stage 1 p723, Fig. 20-37, -38 Condensation of 3 acetyl-CoA units to mevalonate
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Cholesterol Synthesis: Stage 1 Fig 14-10 (p468)
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HMG-CoA synthase Different from mitochondrial HMG-CoA synthase, which plays a role in Ketogenesis
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Lecture_17_3-30-10-PDF_41479 - review Lec16 5. Regulation...

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