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MT SP06 montal (1)

MT SP06 montal (1) - Compiled midterm answer key 1 a(2.5pt...

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Compiled midterm answer key 1. a. (2.5pt) Identify the structural motifs shown in the digrams a and b First structure: Globin Fold Second structure Alpha-Beta Barrel Excepted alpha loop alpha because it said motif b. (2.5pts each) Give one example of a protein each one of these motifs. Golbin Fold- hemoglobin or myoglobin Alpha beta barrel- TIM, troisephosphate isomerase c. (5pts ea) Draw the topographical diagram for each motif. d. Select the appropriate stru ture from the two examples above which displays an active site. Label the location of t he active site (2pts). Describe and explain your choice here (not more than 3 sentences). (3pts) Of the alpha beta barrel in the loop region of the carboxyl end of the beta strand and amino end of alpha helix. Because of molecular interactions of residues in the loop region. 2. (10pts total) True/False. If true mark true, if false cross out word that makes it false and write in a word that makes it true. (2pts each) a. Leucine-rich motifs stabilize the Beta-loop-alpha structure through Van der wal interactions of the leucine residues. TRUE b. Leucine residues in the Beta strand as well as leucine residues in the alpha helix pack together to form a HYDROPHOBIC core. d. Hydrogen bonding occurs between NH and C=O groups in an a helix TRUE e. The main chain of a protein is HYDROPHILIC . f. Weak interactions that help to stabilize protein structures include (DELETE DISULFIDE BONDS) hydrogen bonds and hydrophobic interactions. 3. (25pts total) Which are the two most frequent DNA recognition motifs?
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a. - (2.5pts each) List them Accepted: Helix-turn-helix Helix-loop-helix Zinc finger (cluster) Leucine zipper b. – (5pts each) Draw a schematic diagram of each one of them and label specific components as necessary Schematics needed to draw the basic form of both structures listed in your answer to part a and to label them properly, including their termini (N and C), their important residues (ie for zinc fingers, label the Zn, the cysteines and the histidines), and their important domains (ie the basic and dimerization areas for a leucine zipper). c. – (2.5pts each) Give one example of each one Zinc finger (cluster)=TFIIA, Xfin, Zif268, glucocorticoid, Gal4 Helix-turn-helix=represor, cro, etc Leucine zipper=Gcn4, C/EBP, Fos, Jun, Myc d. – (5pts) Explain how they interact with DNA. Be concise and specific.
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