16. Which statement(s) is/are true about prion diseases? 1. Chronic Wasting Disease in deer, Visna in sheep, and Bovine Spongiform Encephalopathy (BSE) in cattle, are all slow diseases due to prions 2. Inflammatory response is observed in amyloid plaques of Germann-Straussler Syndrome and Variant Creutzfeldt-Jakob Disease patients 3. Medical instrument contaminated by beta-sheet rich, protease-resistant central cores of PrP c cannot be sterilized by heat, soap, or alcohol 4. CJD is not inherited, but can occur in sporadic forms in 1/1,000,000 individuals, and can be acquired by ingestion and iatrogenic routes 5. Early clinical signs of the new variant of CJD, which mainly affects young people, include myoclonus, presenile dementia, tremors, and dysarthria Select the best answer: A. None of the above B. All of the above C. 1, 2, 3 D. 3 E. 3, 5 17. Which statement(s) is/are true about the assembly of viral coat protein? 1.
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