D. 3, 4, 5 E. 4, 5 37. Which statement(s) is/are true about the assembly of viral coat protein? 1. At pH = 7, if all 4S dissociated protein subunits are taken out from a pool of Tobacco Mosaic Virus (TMV) protein subunits, the equilibrium shifts toward the dissociation of 20S disks into 4S subunits 2. At pH = 4.5, the carboxylic groups (Aspartic or Glutamic Acid) of Cowpea Chlorotic Mottle Virus (CCMV) are at equilibrium with 50% them protonated and 50% deprotonated 3. The elongation of tobacco mosaic virus (TMV) protein subunits is bipolar, with the elongation for 3’ end direction faster than for 5’ end direction 4. Polymerization of TMV-protein subunits is favored by low temperature because the assembly of dissociated subunits into helix results in decrease in entropy and thus release heat to the surroundings 5. The assembly of TMV coat protein is initiated when the hairpin loop of TMV mRNA goes into the hole of a 17S disk and dislocate the disk into “washer” shape Select the best answer: A. All of the above B. None of the above
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