4K - Net ID _KEY A_ QUIZ 4a 9/30/09 1. (12 pts) Draw O2...

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D Net ID ____KEY A _____ QUIZ 4a 9/30/09 1. (12 pts) Draw O 2 binding graphs , LABEL THE AXES . Show oxygen binding, not the binding of any other molecules. Write two numerical values including units if any ,on each axis . Label as A, B, C, D, E showing: A. adult Hb, without BPG B. adult Hb + BPG C. Hb that has been dissociated into individual, separated α and β chains. D. Hb + BPG with 2 CO (carbon monoxide) bound E. fetal Hb (+ BPG) 2. (4 pts) Name two negative allosteric effectors of Hb: _ BPG ____ and __ H+ ____ CO2 ALSO OK Name two positive allosteric effectors of Hb: __ O2 ___ and ___ CO ____ 3. (4 pts) Circle T if true, F if false: T F The III structure of Hb α chain, Hb β chain, and Mb look very much the same. T F The I structure of Hb α chain, Hb β chain, and Mb look very much the same. T F Like Hb, Mb changes its oxygen binding when pH changes, as described by the Bohr Effect. T F Hb + BPG has a higher Hill coefficient for oxygen binding than does Mb at all physiological pO 2 . 4. (4 pts) The equilibrium constant K eq for the binding of O 2 to Mb is 2 x 10 6 M -1 , where K eq = [MbO 2 ]/[Mb][O 2 ] . The rate constant for combination of O 2 with Mb is 1 x 10 7 M -1 sec -1 . What is the rate constant for dissociation of O 2 from Mb? K
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4K - Net ID _KEY A_ QUIZ 4a 9/30/09 1. (12 pts) Draw O2...

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