NIF-mod-K08 - Net ID 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12....

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Net ID KEY BIOBM 3310 FINAL EXAM 12/15/08 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. TOTAL WRITE/PRINT LEGIBLY . IF WE CAN'T READ IT, WE CAN'T GRADE IT! LAST PAGE: CHART OF "ALL METABOLISM" PRINT NAME (LAST, FIRST) ON THE BACK TOP OF THE LAST PAGE ONLY
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1. (1 pt) In the early days of biochemistry, before computers and even before any protein structure had been determined, two brothers, Billy Bob Lehninger and Bubba Lehninger, invented the first version of PyMOL. However, their students were not satisfied with the assigned homework, since no images could be seen. In those early days, what one area of biochemistry was actually being studied (circle the letter): A. working out metabolic pathways B. finding examples of 2-state R-T transitions C. solving the protein folding problem D. rational drug design 2. QUESTIONS ABOUT DRAWING MOLECULES a. (3 pts). Draw the structure of the triacylglycerol having all acyl chains 5:1 2 . Show all atoms. b. (6 pts) Draw the structure of Cys-Ala at pH 7 . Cys sidechain is CH 2 SH pKa = 8, Terminal amino pKa = 9 and terminal carboxyl pKa = 4. Ala sidechain is CH 3 . Show every atom. Pick one of the C α , label it, and show the ϕ and ψ angles. c. (4 pts) Start with CH 4 . Draw 4 more 1-carbon molecules showing increasing levels of oxidation. Draw all atoms! atoms! MANY ANSWERS POSSIBLE, BUT HERE IS ONE: CH 4 CH 3 OH C = O CH-OH O = C = O O || H H α
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3. QUESTIONS ABOUT CONTROL OF METABOLISM a. (6 pts) Acetyl-CoA is a key molecule, connected to many metabolic pathways. Choose two examples of metabolic pathways that start from Acetyl-CoA. Name the pathway, then name one molecule that inhibits, one molecule that activates the overall pathway. Choose your 2 pathways wisely so that you can describe the inhibition and the activation: MANY ANSWERS ARE POSSIBLE, BUT 3 THAT WE DISCUSSED IN CLASS: metab 1 is _ ketone body formation or _ CAC cholesterol syn or FA syn It is inhibited by ________________ It is activated by ________________ metab 2 is ___________________ It is inhibited by ________________ It is activated by ________________ b. (4 pts) Regarding control of fatty acid synthesis , name (abbreviations OK) the molecules indicated: One hormone, INSULIN and one small molecule, CITRATE that promot e FA synthesis One hormone, GLUCAGON or EPINEPHRINE and one small molecule, PALMITOYL-CoA that inhibit FA synthesis c. (2 pts) Heart muscle cells respond differently to hormones than do liver cells. Name the two types of proteins that are responsible for the different hormone response in the two tissues: i. CELL SURFACE RECEPTORS ii. DIFFERENT ENZYMES INSIDE THE CELL (e.g. ISOZYMES) d. (8 pts) After eating a meal, normal individuals feel fine, but Billy Bob feels awful. Examination of Billy bob's liver cells show that they fail to respond to insulin. The problem is the lack of insulin receptors in the plasma membrane. After eating a meal, compared to individuals with normal liver function, would Billy Bob's liver cells have
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NIF-mod-K08 - Net ID 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12....

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