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09-1-10

# 09-1-10 - The Nernst equation Chemical certainty if ion...

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The Nernst equation Chemical certainty, if ion gradients are known. E ion =2.303 X RT/zF X log [ion out ]/[ion in ] At body temp., for K+ = 61.54 mV log K out /K in Note: the convention is to show ratio as outside ion concentration/ inside ion concentration. This calculation will give –80 mV for a normal mammalian potassium gradient. (5/ 100 = 0.05, log 0.05= -1.3; -1.3 X 61.54 = -80 mV)

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Nernst equilibrium potential for Na+ Again a chemical certainty, if ion gradients are known. E ion =2.303 X RT/zF X log [ion out ]/[ion in ] At body temp., for K+ = 61.54 mV log Na out /Na in This calculation will give +61.54 mV for a normal mammalian sodium gradient. (120/ 12 = 10, log 10 = 1.0 ; 1.0 X 61.54 = + 61.54 mV)
The electrical impulse (also known as the action potential or AP or spike) What makes an excitable cell excitable? OR: Why only nerve, muscle, and certain gland cells can fire an electrical impulse.

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Answer: Correct mix of Voltage- gated ion channels Resting membrane potential does not require voltage-gated channels, but electrical impulses do.
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