09-08-2010 - Synapse History about its discovery Synapse...

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Synapse History about its discovery Synapse structure The synaptic properties The neurotransmitters Presynaptic vesicle recycling
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Takamori et al., 2006
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The synaptic vesicle cycle loading docking priming calcium sensing fusion endocytosis translocation sorting mobilization storage
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Three principal steps: 1. Docking Docked vesicles lie close to plasma membrane (within 30 nm) 2. Priming Primed vesicles can be induced to fuse with the plasma membrane by stimulations. 3. Fusion Vesicles fuse with the plasma membrane to release transmitter. The ‘active zone’ is the site of physiological release, and can be recognized as an electron-dense structure. Synaptic vesicle exocytosis
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Docking Priming Ca 2+ Fusion Vesicle reserve Pre- Vesicle pools Morphologically, vesicles are classified as docked or undocked. Docked vesicles are further subdivided into primed and unprimed pools depending on whether they are competent to fuse when cells stimulated.
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Docking: Munc-18 is necessary for vesicle docking
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This note was uploaded on 09/19/2010 for the course BIOS 286 taught by Professor Murphy during the Fall '06 term at Ill. Chicago.

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09-08-2010 - Synapse History about its discovery Synapse...

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