- Synapse Postsynaptic receptors(ionotropic Postsynaptic receptors(Metabotropic 1 2 G-protein activation Second messenger systems Synaptic

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Synapse Postsynaptic receptors (ionotropic) Postsynaptic receptors (Metabotropic) 1. G-protein activation 2. Second messenger systems
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Synaptic receptors Two types in the context of nervous system: ionotropic metabotropic Ionotropic receptors are usually ion channels (nicotinic acetylcholine receptor). Initiate a rapid , strong electrical response in the postsynaptic cell. Metabotropic receptors are coupled with G proteins and initiate a signal transduction cascade (muscarinic acetylcholine receptor). Initiate a biochemical cascade that is slower but longer lasting
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Ionotropic receptors 1. Multimeric proteins (subunits) AMPA receptor Nicotinic receptor
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Synaptic receptors Ionotropic receptor GABA Neurotransmitter Acetylcholine Glutamate GABA A Nicotinic AMPA NMDA Kainate Metabotropic receptor GABA B Muscarinic Metabotropic glutamate receptor
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Iontoropic receptor Metabotropic receptor Metabotropic receptors activate G-proteins, which in turn effect other proteins (‘effectors’).
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This protein has 7 transmembrane domains.
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This note was uploaded on 09/19/2010 for the course BIOS 286 taught by Professor Murphy during the Fall '06 term at Ill. Chicago.

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- Synapse Postsynaptic receptors(ionotropic Postsynaptic receptors(Metabotropic 1 2 G-protein activation Second messenger systems Synaptic

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