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330-10 JP 38

330-10 JP 38 - BISC 330L Sp2010 Lect JP38 Monday 19 April...

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Unformatted text preview: BISC 330L Sp2010 Lect JP38.ppt Monday, 19 April 2010 Petruska Lecture 37 (NADH-Q Reaction) Cont’d and Lecture 38: Electron Transport Chain & Proton Pumps References: Berg, Tymocko & Stryer, Biochemistry (6th Ed 2007), Chap. 18 Garrett & Grisham, Biochemistry (3rd Ed 2005), Chap. 20 Biochemistry Sixth Edition Chapter 18: Oxidative Phosphorylation Copyright © 2007 by W. H. Freeman and Company Berg • Tymoczko • Stryer (Read Sections 18.2 & 18.3) Complex I Uses NADH to Reduce Q to QH 2 and also “Pump” H + Complex I: NADH-Q Oxidoreductase (NADH Dehydrogenase) • Electron transfer from NADH (matrix) to coenzyme Q (UQ) in inner membrane • Complex structure with 46 subunits (poorly resolved) of which 7 are encoded by mitochondrial genome & 39 are imported from cytoplasm by TOMs & TIMS. • Net reaction catalyzed by Complex I: + + + Complex I: NADH-Q Oxidoreductase NADH + Q + 5 H + matrix NAD + + QH 2 + 4H + cytoplasm i.m. space------------------- (Problem: Using Table 18.1, calc. ∆ G o ’, to see if sufficient to pump 4H + ) H + + 2 H + pH 7 pH 5 [Fe-S] Calculation of ∆ G o ’ from ∆ E o ’ for Q reduction by NADH: NADH + H + + Q NAD + + QH 2 Half-reactions (Table 18.1): Acceptor: Q + 2H...
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330-10 JP 38 - BISC 330L Sp2010 Lect JP38 Monday 19 April...

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