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5 BISC_120 MolecInheritance

5 BISC_120 MolecInheritance - Reminders Clicker questions...

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Reminders • Clicker questions included in every lecture – Must answer all questions in a lecture to get one point for that lecture – 20 randomly chosen lectures will be used to determine up to 20 points toward your final grade • Requests for academic accommodations based on a disability are due Friday 2 4) Molecular basis of inheritance • 15.1 - 15.3 and 16.1 3 We now know that Mendel’s “hereditary factors” are located on chromosomes Fig. 15.1 4 Early studies of meiosis showed that the behavior of chromosomes parallels the behavior of Mendel’s “factors” • Both chromosomes and “factors” – Present in pairs in diploid cells – Segregate during meiosis – Halve their copy numbers during meiosis and double their copy numbers at fertilization BioFlix video (ch 13) from masteringbio.com
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5 Thomas Hunt Morgan ’s fruit fly experiments provided the first strong evidence that genes are on chromosomes 6 Why fruit flies? • Easy to rear in lab • Short generation time (~10d) • Abundant offspring (100s per mating) • Only 4 pairs of chromosomes • Numerous mutation stocks now available 7 Fig. 15.3 P Generation F 1 Generation F 2 Generation P Generation F 1 Generation Ova (eggs) Sperm F 2 Generation Ova (eggs) Sperm Morgan’s explanation Fig. 15.4
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