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MCB3209%20Ch2%20slides

MCB3209%20Ch2%20slides - H2O Cholera cots Diabetes...

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H 2 O
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Cholera cots
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Diabetes
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Elephantiasis
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Pulmonary edema
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Insert fig. 2.7 Fig. 2.7 Covalent bond Polar covalent bonds between H and O of H 2 O Weak hydrogen bonds among H 2 O molecules
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Na + and Cl - dissolve in water NaCl Na + + Cl - electroneutrality hydrophilic
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Na + and Cl - dissolve in water NaCl Na + + Cl - electroneutrality hydrophilic positive cation negative anion
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Concentrations Concentration = molecules/volume = moles/liter or molar M Mole = 6.02 x 10 23 molecules 1 M = 6x10 23 mols/liter Example : 70 kg person 60% of total weight (70 liters) is water = 42 liters 33% extracellular or 14 liters 67% intracellular 28 liters [Na + ] in blood and extracellular fluid = 0.15 M 0.150 M = 150x10 -3 M or 150 mM
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Sweating - [Na + ] regulation example
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Sweating - [Na + ] regulation example Conc = moles/l less water moles of Na + constant [Na + ] increases Negative feedback: Brain senses [Na + ] Hormone released Dry mouth, thirst • Drink • [Na + ] decreases
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Acidic Basic or alkaline pH = - log [H + ]
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pH regulation example • Diarrhea lose alkaline fluid
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