Ch12.2-1 - Which of the following occurs in a cell as a...

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Which of the following occurs in a cell as a result of insulin binding to its receptor? A. Cyclic GMP is produced. B. Glucose is released from the cell. C. The glucose transporter GLUT4 moves from the plasma membrane to internal membrane vesicles. D. Glycogen synthase becomes activated.
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Fig. 12-1 The affinity between signal (ligand) and receptor is typically high on the order K d ~10 -10 M or less. Signal Transduction -- four important features…
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Fig. 12-1 happens within milliseconds!
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Fig. 12-1
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Fig. 12-1
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Different types of receptors and different ways to respond… 1 2 3 4 5 •signal interacts with receptor receptor interacts with cellular machinery •produces change in the target cell’s metabolic activity •finally, transduction event terminates and cell returns to prestimulus state
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Fig. 12-4 •Signal [ligand] falls below K d •G protein’s intrinsic GTPase •PDE degrades cAMP •Phosphatases reverse PKA phosphorylations Termination GPCRs -- e.g. -adrenergic receptor
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Regulation of gene expression by insulin (RTK): Fig. 12-15 IRS-1= Insulin receptor substrate-1 Grb2 an adapter protein (no intrinsic enzyme activity) Ras = monomeric G protein MEK = mitogen-activated ERK kinase ERK = extracellular regulated kinase SRF = serum response factor The signal pathway is an example of a MAP kinase cascade . What type of signal cascade is this?
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Insulin lowers blood glucose and increases glycogen synthesis: Fig. 12-16 How does PI-3K bind to IRS-1? Via PI-3K SH2 domain binding to IRS-1 P-Tyr residue
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Chapter 12 Gated ion channels Sensory transduction
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Which of the following occurs when a presynaptic neuron releases acetylcholine into the synaptic cleft? A. The acetylcholine receptor channel of the postsynaptic neuron closes. B.
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This note was uploaded on 09/21/2010 for the course CH 53380 taught by Professor Raymond during the Spring '10 term at University of Texas.

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Ch12.2-1 - Which of the following occurs in a cell as a...

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