Ch18.2 - The coenzyme required for all transaminations is derived from A niacin B pyridoxine(vitamin B 6 C riboflavin D thiamin E vitamin B 12

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Unformatted text preview: The coenzyme required for all transaminations is derived from: A. niacin. B. pyridoxine (vitamin B 6 ). C. riboflavin. D. thiamin. E. vitamin B 12 . Figure 18-2a Overview of amino group catabolism (vertebrate liver). Glutamate DH Net: 2NH 4 + + HCO 3- + 3ATP + H 2 0 urea + 2ADP + 4P i + AMP + 2H + Chapter 18 -- Amino Acid Degradation Chapter 18 -- Amino Acid Degradation The fate of the “carbon skeletons” Which of the following amino acids can be converted to α-ketoglutarate? A. aspartate B. leucine C. methionine D. proline Figure 18-1 Amino acid catabolism in mammals Pathways of Amino Acid Degradation Figure 18-15 Which amino acid groups can be converted into glucose? Pink = glucogenic Blue = ketogenic 20 amino acids 6 major products Formation of Ketone Bodies Figure 17-18- derived from acetyl-CoA (via catabolism of fatty acids and ketogenic amino acids)-can provide an alternative energy source for brain when glucose is scarce The catabolism of amino acids involves many different pathways and many different kinds of chemical reactions. But there are some “classes” of reactions that occur often and some common cofactors involved. We already talked about one class: transaminations (PLP) One carbon transfer reactions also very important in amino acid and nucleotide metabolism (chapter 22). Cofactors involved in one carbon transfers include: biotin, S-adenosylmethionine and tetrahydrofolate Structures of enzyme cofactors involved in one carbon transfers: Another cofactor: Tetrahydrobiopterin Not involved in one-carbon transfers, so we’ll consider it Later. Interconversion of...
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This note was uploaded on 09/21/2010 for the course CH 53380 taught by Professor Raymond during the Spring '10 term at University of Texas at Austin.

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Ch18.2 - The coenzyme required for all transaminations is derived from A niacin B pyridoxine(vitamin B 6 C riboflavin D thiamin E vitamin B 12

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