Ch21.2 - Review Acetyl-CoA Carboxylase: activation of...

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Review
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Acetyl-CoA Carboxylase: activation of acetyl-CoA Acetyl-CoA + ATP + HCO 3 Malonyl-CoA + ADP + P i (Biotin is temporary carrier of carboxylate group) Figure 21-1
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The general scheme for making fatty acids:
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Figure 21-5/6 The Cycle: 1. Condensation 2. Reduction 3. Dehydration 4. Reduction 5. Translocation 6. Recharging
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Phosphatidic acid is synthesis Figure 21-17
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Figure 21-18 Phosphatidic acid precursor for TAGs or glycerophospholipids This is where the pathway branches:
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Chapter 21 -- Lipid Biosynthesis cont. •Synthesis of membrane lipids •Synthesis of cholesterol
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Figure 10-6 Synthesis of membrane lipids
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Figure 10-8 Figure 10-9
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Figure 10-12 What type of bond is this? amide
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Lipid composition of the plasma and organelle membranes of a rat hepatocyte
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Figure 21-18 Phosphatidic acid used to form TAG or glycerophospholipid
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Figure 21-23 Polar Head-group attachment
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Figure 21-24 Eukaryotes use both strategies Prokaryotes only use strategy 1
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Bacteria, yeast and mammalian liver Pathways to PC, PS and PE
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Figure 21-25 E. Coli uses strategy 1 to synthesize common glycerophospholipids cardiolipin phosphatidylethanolamine
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Figure 21-25 Bacteria use phosphatidylglycerol 3-phosphate and phosphatidylserine to synthesize cardiolipin and phosphatidylethanolamine
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Figure 21-26 Eukaryotes also use strategy 1 for some glycerophospholipid synthesis PG made as in bacteria (see 21-25)
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Yeast make PS and PE like E. coli (i.e. strategy 1 )… Synthesis of glycerophospholipids in yeast This reaction also occurs in mammalian liver cells.
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in all tissues besides liver… (strategy ) 2 PE is synthesized in a similar pathway from ethanolamine in mammalian cells
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This note was uploaded on 09/21/2010 for the course CH 53380 taught by Professor Raymond during the Spring '10 term at University of Texas at Austin.

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Ch21.2 - Review Acetyl-CoA Carboxylase: activation of...

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