Bacterial Resistance Articles *Large majority of antibiotics used for treating infections & resistance genes acquired by humans pathogens each have an environmental origin (emerged in nonclinical habitats); produced by microorganisms *change in environment/ecosystems including release of antimicrobials might alter population of microorganisms including selection for resistance Ecological Role for Antibiotics in Natural Environments Finding of antibiotics in soil leads to the idea that they serve in inhibiting growth of competitors (molecules selected in nature are at lower concentrations in nature though) Trigger transcriptional changes independent of bacterial stress response pathway and may be beneficial for bacteria that modulate interactions within microbial communities *subinhibitory concentrations of antibiotics could possibly favor virulence under certain conditions Why So Many Resistance Genes? Antibiotics as a source of nutrients to bacteria
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This note was uploaded on 09/23/2010 for the course BIO Biology 14 taught by Professor Escobar during the Fall '10 term at Emory.