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C8e_21_Test_Bank - Biology 8e(Campbell Chapter 21 Genomes...

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1 Biology, 8e (Campbell) Chapter 21 Genomes and Their Evolution Multiple-Choice Questions 1) For mapping studies of genomes, most of which were far along before 2000, the 3-stage method was often used. Which is the usual order in which the stages were performed, assuming some overlap of the three? A) genetic map, sequencing of fragments, physical map B) linkage map, physical map, sequencing of fragments C) sequencing of entire genome, physical map, genetic map D) cytogenetic linkage, sequencing, physical map E) physical map, linkage map, sequencing Answer: B Topic: Concept 21.1 Skill: Application/Analysis 2) What is the difference between a linkage map and a physical map? A) For a linkage map, markers are spaced by recombination frequency, whereas for a physical map they are spaced by numbers of base pairs (bp). B) For a physical map, the ATCG order and sequence must be achieved, but not for the linkage map. C) For a linkage map, it is shown how each gene is linked to every other gene. D) For a physical map, the distances must be calculable in units such as nanometers. E) There is no difference between the two except in the type of pictorial representation. Answer: A Topic: Concept 21.1 Skill: Knowledge/Comprehension 3) How is a physical map of the genome of an organism achieved? A) using recombination frequency B) using very high-powered microscopy C) using restriction enzyme cutting sites D) using sequencing of nucleotides E) using DNA fingerprinting via electrophoresis Answer: C Topic: Concept 21.1 Skill: Knowledge/Comprehension 4) Which of the following most correctly describes a shotgun technique for sequencing a genome?
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2 5) The biggest problem with the shotgun technique is its tendency to underestimate the size of the genome. Which of the following might best account for this?
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