103Lect4Sp10

103Lect4Sp10 - BIS 103 Slides 4/8/10 F e r m e n ta tio n A...

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BIS 103 Slides 4/8/10 Fermentation Alcohol Metabolism in Humans Enzyme classes Catabolism of other Carbohydrates
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1 GLC + 2 ATP 2 G-3-P + 2 ADP 1 GLC + 2ADP + 2Pi + 2NAD + 2 PYR + 2 ATP + 2NADH + 2H 2 O 2 G-3-P + 2Pi + 4 ADP + 2 NAD + 2 PYR + 4 ATP + 2NADH + 2H 2 O Summary of 10 steps into 2 phases 1.Costs ATP to make ATP! 2. For flux through glycolysis to continue, need to recycle NADH back to NAD+ Low concentrations, Is rapidly consumed Done different ways- HB pg 17 Steps 1-5 Steps 6-10
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NADH recycling back to NAD+
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C O CH 3 O -O C H CH 3 O -O PYR HO LACTATE LACTIC ACID FERMENTATION 11 NADH + H + NAD + FINAL STEPS OF TWO DIFFERENT FERMENTATION PATHWAYS lactic acid fermentation occurs- 1. Mammalian cells- skeletal muscle, mature RBCs, cardiac muscle, glial cells 2. Plant roots, usually not leaves 3. Certain bacteria- eg., Lactobacillus family + others- intestinal flora, yogurt Streptococcus mutans- anaerobic bacteria in mouth-lactic acid lowers pH, which dissolves enamel HB pg 17 LDH LDH = Lactate dehydrogenase Partial list:
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Anaerobic Glycolysis is an Internal Oxidation-Reduction Process C OH CH 3 O -O H LACTATE C OH CH 3 O -O H CHO OH H H HO OH H OH H CH 2 OH GLC 1 2 3 4 5 6 1 2 3 4 5 6 In toto, there is no net oxidation-reduction of the carbons HB pg 18 To see this, use the oxidation number system: For each bonded H, assign a value of -1 For each bonded C, assign a value of 0 For each bonded O, S, or N, assign a value of +1 For a double bond, multiply the number by 2 For a triple bond, multiply the number by 3 +1 0 0 0 0 -1 0 -3 0 +3 +3 0 -3 0 Rearrangement Yields net of 2 ATP!
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C O CH 3 O -O O CH 3 H CH 2 OH CH 3 PYR ALCOHOLIC OR ETHANOLIC FERMENTATION 12 ACETALDEHYDE ETHANOL 13 NADH + H + NAD + CO 2 FINAL STEPS OF TWO DIFFERENT FERMENTATION PATHWAYS ethanolic fermentation occurs 1. Plant roots, typically not leaves 2. Certain microbes- yeasts 3. NOT in Humans Catabolism of ethanol does occur in human liver- Humans do have ADH ADH PDC HB 17
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Alcohol Catabolism in Humans An relevant aside…
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H CHO OH H HO OH H OH H CH 2 OH H CHO OH H HO OH H OH H CH 2 OPO 3 2- GLC-6-P GLC ATP ADP CH 2 O H HO OH H OH H CH 2 OPO 3 2- ATP ADP CH 2 OPO 3 2- O H HO OH H OH H CH 2 OPO 3 2- CH 2 OPO 3 2- O CH 2 H HC OH CH 2 OPO 3 2- + HPO 4 2- NAD + NADH H C OH CH 2 OPO 3 2- O OPO 3 2- ATP ADP H C OH CH 2 OPO 3 2- O - O H C OPO 3 2- CH 2 O - O C OPO 3 2- CH 2 O - O C O CH 3 O - O ATP ADP F-6-P DHAP G-3-P 1,3 bisPGA 3-PGA 2-PGA PEP PYR H 2 O 1 2 3 4 5
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103Lect4Sp10 - BIS 103 Slides 4/8/10 F e r m e n ta tio n A...

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