Endocrine-Topic3Sp10.pptx

Endocrine-Topic3Sp10.pptx - Topic #3 Endocrinology 1 Growth...

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Topic #3 Endocrinology 1 Growth Hormone (GH) Secretion and Its Actions (optimal effects require normal thyroid hormone levels & Insulin– for IGF activity) 5/18/10 1 Inhibits Stimulates HHPS Secretes Direct Metabolic Effect Direct Metabolic Effect Produces Produces Growth Effects Occur Through Stimulates Hypothalamus GHRH Hypothalamus Somatostatin (GHIH) Decrease Blood Glucose Increase AA During Deep Sleep Decrease FA Exercise Stress Fasting Anterior Pituitary Stimulates Somatotrophs GH Adipose Tissue Decreases Uptake FA Increases Lipolysis. Shifts metabolism to lipids & away from carbohydrates Decreases Adiposity - Loss of "Baby Fat" Muscle Tissue Increase AA Uptake Increase Protein Synthesis Decrease Glucose Uptake Increase in Lean Body Mass Somatomedin (IGF-I) Synthesized by Liver & other tissues (bone and cartilage) Requires Insulin All the Growth Effects Bone Growth Cell Division Organ Growth Organ Function 5-27-08 Glucose Sparing Effect
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Topic #3 Endocrinology 2 Feedback Control of Growth Hormone Secretion 5/18/10 2 Hypothalamus Stimulates Stimulates Inhibits Stimulates Inhibits GHRH GH Somatotrophs Anterior Pituitary IGF-1 Somatomedins Somatostatin GHIH (Paracrine Effect) 5-27-08
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Topic #3 Endocrinology 3 Abnormalities in Growth Hormone Secretion or Responsiveness to Growth Hormone 5/18/10 3 Excess Growth Hormone Prior Puberty & Prior to Closure of the Growth Plates in the Long Bones Gigantism – 8 ft Tall – Proportional Growth of Skeletal and Muscle Tissue Excess Growth Hormone Post Puberty (Growth Plates Long Bones Closed) Acromegaly – Growth of Soft Cartilaginous Tissue – Enlarged, Protruding Cheek Bones; Enlarged, Protruding Sternum and Ribs; Enlarged hands and Feet (Fig. 18-14) Deficiency Growth Hormone Prior to Puberty Dwarfism – small body size, may have poor muscle development, subcutaneous fat – baby fat (pudgy). occurs because of deficiency Growth Hormone, or normal Growth Hormone but lack of Growth Hormone receptors, or normal Growth Hormone but low leves of IGF-1. African Pigmy
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This note was uploaded on 09/23/2010 for the course NPB 8746546 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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Endocrine-Topic3Sp10.pptx - Topic #3 Endocrinology 1 Growth...

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