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Lect7powerpointslides - Slides Biosynthetic Function of TCA...

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Unformatted text preview: Slides 4/20/10 Biosynthetic Function of TCA Anapleurotic Reactions Gluconeogenesis Poly- and Di-saccharide Synthesis Metabolic Role of Lactate in Humans C O H 3 C SCoA CH 2 COO- CH 2 COO- HO COO- CH 2 COO- C CHCOO- COO- CH 2 COO- C H COO- COO- OH CH 2 COO- C H H COO- O CH 2 COO- C H H ScoA O + CO 2 COO- CH 2 CH 2 COO- GDP + Pi GTP + CoASH COO- C C- OOC H H C COO- C H HO H H COO- + H + ISOCITRATE !-KETO- GLUTARATE SUCCINYL CoA C COO- H 2 C COO- O Acetyl CoA TCA CYCLE CITRATE cis-aconitate enzyme-bound OXALOACETATE FUMARATE SUCCINATE MALATE 1 2 3 4 5 6 7 8 CoASH + H + 2 NAD NADH CO 2 NAD NADH CoASH FADH 2 FAD H 2 O NAD NADH H 2 O H 2 O H 2 O H 1 H 2 C CH 2 COO- HO COO- C SCoA O NZ bound intermediate citryl CoA C o m m o n S y s t e m a t i c . 1. citrate synthase citrate OAA-lyase (acetyl CoA forming) 2. aconitase citrate hydro-lyase 3. isocitrate dehydrogenase isocitrate:NAD+ oxidoreductase(decarboxylating) 4. !-ketoglutarate dehydrogenase complex !-ketoglutarate dehydrogenase system 5. succinyl CoA synthetase succinate:CoA ligase (GDP forming) 6. succinate dehydrogenase succinate:FAD oxidoreductase 7. fumarase malate hydro-lyase 8. malate dehydrogenase (MDH) malate:NAD+ oxidoreductase HB 33 PYR OAA Acetyl CoA (mito) Citrate !-KG Succinyl CoA Fumarate Malate Isocitrate Succinate Fatty Acids Glutamate Steroids Glutamine Proline Glutathione Ornithine Arginine Aspartate Threonine Methionine Lysine Pyrimidine bases Porphyrins Chlorophyll Vit B12...
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Lect7powerpointslides - Slides Biosynthetic Function of TCA...

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