lecture11Powerpt

lecture11Powerpt - Hormonal Control of Carbohydrate...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Hormonal Control of Carbohydrate Metabolism in Humans and Fatty Acids and FA Breakdown May 4, 2010 2 C C C R R Allosteric Regulation of cAMP dependent protein kinase (PKA) N N N N NH 2 O H OH H H H H O P O O- O P O O- O P-O O- O O N N N N NH 2 O H O H H H H P O-O cAMP (cyclic AMP) O- P O O- O P-O O- O Adenylate cyclase N N N N NH 2 O H OH H H H H O P-O O- O H 2 O O- P HO O- O 2 H 2 O Phosphodiesterase AMP ATP Synthesis and degradation of cAMP Inactive Protein Kinase A also called inactive cAMP-dep Protein Kinase + R 2 4 cAMP x 4 Active Protein Kinase A also called active cAMP-dep Protein Kinase (a serine/threonine kinase) C R Activation of PKA catalytic subunit of PKA regulatory subunit of PKA In the absence of cAMP, the regulatory subunits re-associate with the catalytic subunits, inactivating PKA HB 49 Allosteric regulator REVIEW 2 C Active Protein Kinase A AKA active cAMP-dep Protein Kinase (a serine/threonine kinase) Phosphorylase b kinase less active form Phosphorylase b kinase more active phosphorylated form ATP ADP ATP ADP ATP ADP ATP ADP Phosphorylase b less active form Phosphorylase a more active phosphorylated form Glycogen synthase I more active form glucose-6-P indep. Glycogen synthase D less active , phosphoryl. form glucose-6-P dep. High rate of Glycogen breakdown Slow rate of Glycogen breakdown H 2 O HPO 4 3- HPO 4 3- H 2 O Covalent Modification Regulates Mammalian Glycogen Metabolism in liver,muscle in liver,muscle Bifunctional PFK-2/F-2,6BPase more active/less active Bifunctional PFK-2/F-2,6BPase less active/more active in liver only...
View Full Document

This note was uploaded on 09/23/2010 for the course NPB 8746546 taught by Professor Goldberg during the Spring '10 term at UC Davis.

Page1 / 22

lecture11Powerpt - Hormonal Control of Carbohydrate...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online