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lecture12Slidespowerpoint - F A B re a k d o w n Ketone...

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FA Breakdown Ketone Bodies FA synthesis May 6, 2010 these topics on May 11, 2010 : Glycerolipid Synthesis Cholesterol Glyoxylate Cycle
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REACTIONS OF FATTY ACID ! -OXIDATION acyl carnitine R C O S CoA R C O carnitine Transport into mito (animals) peroxisomes (plants) cytosol (prokaryotes) cytosol- inner membrane space (animals) R C O R C O S CoA acyl CoA acyl CoA mito inner membrane mito inner membrane free fatty acid FFA CoA + ATP AMP + PPi carnitine CoA CoA carnitine free fatty acid:CoA ligase acyl CoA synthetase O- This shows the Carnitine shuttle in mammals only CH 3 N CH 3 CH 3 CH 2 C OH H CH 2 COO - carnitine Only long chain FA HB 56
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trans- ! 2 -enoyl CoA L-3( ! )-hydroxyacyl CoA 3 ( ! )-ketoacyl CoA R C O S CoA R C O S CoA acyl CoA R C O S CoA OH R C O S CoA O R C O S CoA C O S CoA H 3 C acetyl CoA acyl CoA mito matrix TCA cycle ! -OXIDATION FAD FADH 2 H 2 O NAD + NADH + H + CoA more rounds of ! -oxidation 1 2 3 4 + acyl CoA:FAD oxidoreductase L-3-hydroxyacyl CoA hydro-lyase L-3-hydroxyacyl CoA:NAD + oxidoreductase 3-keto acyl CoA: CoA acyltransferase thiolase H α β β β 1 2 1 2 β -C is Oxidized! β α 3 α β HB 56
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! -OXIDATION OF UNSATURATED FATTY ACIDS H 3 C SCoA C O 3 turns of ! -oxidation 9 12 18 1 3 acetyl CoA SCoA C O 7 H 3 C 9 12 18 " ! # SCoA C O 7 H 3 C 9 12 18 " ! # cis- ! 3 , cis ! 6 trans- !
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This note was uploaded on 09/23/2010 for the course NPB 8746546 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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lecture12Slidespowerpoint - F A B re a k d o w n Ketone...

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