Lecture13powerpointslides

Lecture13powerpointslides - Glycerolipid Synthesis...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Glycerolipid Synthesis Cholesterol Glyoxylate Cycle Electron Carriers Electron Transport Chain May 11, 2010
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fatty Acid Biosynthesis C O S CoA H 3 C acetyl CoA ACP C O S ACP H 3 C CoASH C O S CoA H 3 C acetyl CoA HCO 3 - acyl carrier protein ATP C O S CoA C C H H O O - malonyl CoA C O S CoA C C H H O O - malonyl CoA ACP CoASH C O S ACP C C H H O O - Acetyl CoA Carboxylase ADP HPO 4 3- malonyl ACP biotin PKA phosphorylates (Inh) HB 60 Acetyl CoA Carboxylase is a KPIE! Citrate (A) feed forward activation Palmitoyl CoA (I) feedback inhibition LAST TIME:
Background image of page 2
Acyl Carrier Protein has same function as CoA in that both Carry fatty acyl groups Both contain a pantetheine group LAST TIME:
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
C O S ACP C O S ACP C O S ACP HO CH 3 C O S ACP O H H 3 C D-3( ! )-hydroxyacyl ACP Acetoacetyl ACP 3 ( ! )-ketoacyl ACP (Acetoacyl ACP) Butyryl ACP acetyl ACP C O S ACP C C H H O O - C O S ACP H 3 C CO 2 NADPH + H + NADP + H 2 O NADPH + H + NADP + CH 3 use growing chain instead of acetyl ACP in next rounds-repeat reactions 1-4 until C16 1 2 3 4 malonyl ACP FAS Complex + ACP HB 60 LAST TIME:
Background image of page 4
Comparison between FAS and ! -oxidation Feature FA synthesis ! -oxidation Location cytosol, ER (animals) mito, peroxisome (animals) chloroplasts, ER (plants) peroxisome (plants) carrier protein (ACP) CoA co-enzyme substrate NADPH NAD+/FAD stereochemistry D L ATP requirement 1 per 2C's added 2 to activate an intermediate ! -ketoacyl (same) ! -ketoacyl (same) HB 61
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 26

Lecture13powerpointslides - Glycerolipid Synthesis...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online