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Lecture19Sp10powerptslides

Lecture19Sp10powerptslides - F in is h A A b r e a k d o w...

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Finish AA breakdown New cofactor THF N assimilation AA synthesis June 1, 2010
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Fri 6/4 3:10 -5:00 PM 1001 GIEDT Callis, lead Sat 6/5 3:30 -5:30 PM 198 Young Hanine and Jason, lead Sun 6/6 3:40 PM- 5:30 PM 1001 GIEDT Callis, lead Review Sessions for Final
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Extra office hours Jason, Friday June 4rd 10:00-12 pm Room 2061 SLB
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Fate of carbon skeleton from amino acids 20 catabolic paths lead to 7 metabolites! HB 85 Glucogenic: C skeletons are degraded to Pyr, ! KG, Succinyl CoA, Fumarate, or OAA, compounds that all or most of the carbon can be converted to Glucose Ketogenic C skeletons that are degraded to Acetyl or Acetoacetate Amino acid Common metabolite product Ala, Cys, Gly, Ser, Thr (some organisms), Trp Pyr Ile, Leu, Trp, Thr (some organisms) Acetyl CoA Leu, Lys, Phe, Tyr Acetoacetate Arg, Glu, Gln, His, Pro ! KG Ile, Met, Thr (humans), Val, Succinyl CoA Phe, Tyr Fumarate Asn, Asp OAA Breakdown of Amino Acids Know degradation pathways
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HN N N N O H 2 N H CH 2 N H C O H N CH CH 2 CH 2 COO - COO - Folic Acid, Tetrahydrofolic acid (THF) and THF as a Carrier of 1 Carbon Units at different Oxidation States pteridine ring (6-methyl pterin) p-amino benzoic acid glutamate FOLIC ACID 7 6 9 10 8 5 NADPH + H+ NADPH + H+ NADP+ 7,8-Dihydrofolic Acid (DHF) HN N NH H N O H 2 N H CH 2 N H 7 6 9 10 8 5 H H REST 5,6,7,8-Tetrahydrofolic Acid (THF) Dihydrofolate reductase THF as a carrier of C1 units at different oxidation states NAD+ VITAMIN COFACTOR HB 86
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HN NH 5 6 9 10 N N 5 6 9 10 HN NH N N 5 10 ATP ADP + Pi CH O N 10 formyl THF Ser Gly PLP CH 2 OH C H 2 N N N 5 N 10 methenyl THF C H N N NADPH + H+ NADP+ NADPH + H+ NADP+ N 5 methyl THF N 5 N 10 methyleneTHF unstable CH 3 H H HCO 3 - H 2 O H 2 O THF as a carrier of C1 units at different oxidation states HB 86
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HN N N N O H 2 N H CH 2 N H C O H N CH CH 2 CH 2 COO - COO - Folic Acid, Tetrahydrofolic acid (THF) and THF as a Carrier of 1 Carbon Units at different Oxidation States pteridine ring (6-methyl pterin) p-amino benzoic acid glutamate FOLIC ACID 7 6 9 10 8 5
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