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MCB_121_Lecture_01

MCB_121_Lecture_01 - MCB 121 Spring 2010 Molecular Biology...

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1 MCB 121 Spring 2010 Molecular Biology of Eukaryotic Cells Dr. Ted Powers Molecular and Cellular Biology College of Biological Sciences TA: Leyda Evers, CDB Graduate Group Prerequisite: Biological Sciences 101
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2 Goal of class: I. Explore relationship between Genotype and Phenotype Genotype : an organisms genetic constitution or allelic makeup Phenotype : the physical manifestation that results from the expression of this genetic constitution II. Understand the molecular basis for the transition between Genotype and Phenotype: The Central Dogma: DNA --> RNA --> Protein III. Understand how genomes are maintained and propagated IV. Experimental basis for our understanding of these events
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3 “You know, the proper method for inquiring after the properties of things is to deduce them from experiments.” Isaac Newton, 1672
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4 Course Resources : Lectures: PowerPoint Presentations Reading assignments Text Book Additional literature posted as .pdf files Problem Sets Sample Exams Office Hours (Instructor & TA) Basis for Exams: Lectures, Problem Sets, Sample Exams Textbook: Molecular Biology of the Gene, Watson et al. 6 th Edition Resources available on the course website (SmartSite)
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5 Basic Modules for the quarter: I. Lectures 1-4: Introduction to molecular genetics: Genetic analysis: Approaches & Tools II. Lectures 5-7: Protein Synthesis III. Lectures 8-10: DNA related issues IV. Lectures 11-14: mRNA formation/regulation V. Lectures 15-18: RNA processing & beyond Testing/Grades: 2 Midterms (100 points each) Final Exam (100 points) Final grade based on 300 point total All quizzes scantron based (bring UCD 2000 form)
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6
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7 Lectures 1: The Spirit of Molecular Biology: Combining Classical Genetics and Biochemistry to solve an interesting biological problem Reading: Watson: pp. 783-789 Primary: Wood & Edgar Scientific American, 1967 Optional: Jarvik & Botstein Proc. Natl. Acad. Sci. Edgar, Genetics, 2004 Problem Set 1
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8 Genetics versus Biochemistry The Geneticist: Observe and Deduce “The geneticist is inclined to let reproductive processes take their normal course and then, by analyzing progeny, to deduce the molecular events that must have occurred within them” The Biochemist : Grind and Reconstitute “The biochemist is eager to break the organism open and search among the remains for more direct clues to what is going on inside” Wood & Edgar, 1967 Also check out : http://bio.research.ucsc.edu/people/sullivan/savedoug.html
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9 The issue
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