MetabolicConcepts

MetabolicConcepts - Metabolic Concepts F r o m l e c tu r e...

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Metabolic Concepts From lecture 4/30/09
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Metabolic Concepts 1. The inter-conversions of metabolites in cells are highly regulated. To provide molecules only when needed and in the appropriate amounts. To prevent the build-up of unwanted, unneeded intermediates that could be toxic. To prevent complete futile cycling , Futile cycling is when opposing pathways produce their respective products at the same rate (and in the same cell at the same time). If complete futile cycling does occur, no net product will result, but ATP or NADH is consumed.
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Partial futile cycling is when opposing pathways operate at the same time in the same cell, but not quite at the same rate, so some net product is produced. There is some loss of ATP (or NADH). • But there is an advantage to partial futile cycling. • Having opposing pathways operating at the same time gives two points of control. One pathway can be down-regulated, while the other pathway can be up-regulated.
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enzyme-mediated, control of enzyme activity is a major mechanism. This class focuses on understanding how
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MetabolicConcepts - Metabolic Concepts F r o m l e c tu r e...

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