VitaminCoenzymeRelationshipFINAL - Spring 2010 BIS103...

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Spring 2010 BIS103 Vitamin and Co-enzyme Relationship Co-enzyme name and abbreviation Vitamin for humans B name Function Comments Deficiency Disease Thiamine pyrophosphate, TPP Thiamine B1 Decarboxylation of alpha keto acids Enzyme bound Beriberi Flavin Adenine Dinucleotide, FAD Riboflavin B2 Oxidation/reduction (electron transfer) Can be found in 3 forms: FAD (fully oxidized), FADH (semi- reduced or semi-oxidized, FADH2 (fully reduced); almost always protein bound Ariboflavinosis NicotinAmide Dinucleotide (phosphate), NAD, (NADP) Niacin (nicotinic acid, nicotinamide) B3 Oxidation/reduction (electron transfer) Hydride transfer= 2 electrons, 1 proton, both at same time, found only as fully oxidized NAD+, or fully reduced NADH. Protein- bound or releasable as free co- factor. (to participate in reaction has to bind to enzyme), but then can be released. Pellagra (black tongue in dogs) Coenzyme A CoASH/CoA, (also in Acyl Carrier Protein, ACP) Pantothenic Acid B5 An Acyl carrier Acetyl is a 2C acyl unit
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This note was uploaded on 09/23/2010 for the course NPB 8746546 taught by Professor Goldberg during the Spring '10 term at UC Davis.

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VitaminCoenzymeRelationshipFINAL - Spring 2010 BIS103...

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