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Conservation of The Bicoid Gene

Conservation of The Bicoid Gene - Conservation of The...

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Conservation of The Bicoid Gene By Paige Narum University of Colorado, Boulder Genetics, MCDB Section 13 April 20 th TA: Rakel
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Abstract The purpose was to determine if the bicoid gene was conserved between flies and humans using PCR and gel electrophorisis. The specification of anterior positional information during Drosophila embryogenesis is dependent upon the function of the maternal-effect gene bicoid (bcd). Two are two aspects of bcd function. First, the bcd protein product forms a gradient during early embryogenesis, which regulates the transcription of at least one zygotic segmentation gene, hunchback, in a concentration dependent manner. Secondly, formation of the bcd protein gradient is dependent upon the specific localization of bcd mRNAs at the anterior end of the oocyte/embryo during oogenesis.(Roe). Introduction The bicoid gene product is required for anterior positional values in the Drosophila embryo. Females mutant for the bcd gene produce embryos that lack all head, thoracic and anterior abdominal segments. In wild-type eggs, bicoid mRNA is localized in the anterior pole region and the bicoid protein forms an anterior-to-posterior concentration gradient. bicoid activity is required for transcriptional activation of zygotic segmentation genes and the translational suppression of uniformly distributed maternal caudal mRNA in the anterior region of the embryo.(Seeger.)
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