Lecture%202-Basic%20Concepts%20%28Immune%20system%29Slides

Lecture%202-Basic%20Concepts%20%28Immune%20system%29Slides...

Info iconThis preview shows pages 1–16. Sign up to view the full content.

View Full Document Right Arrow Icon
Human Infectious Diseases Human Infectious Diseases Laboratory Location: NMS 3.236 Email: [email protected] Basic Concepts: Host Immunity
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Overview of Immunity Principal biologic role of the immune system is to protect us from microbial infection. Immunity, derived from Latin word immunis (“exempt”) Relatively new Feld of study—just over 100 years. Organs and tissues of the immune system Blood Lymphatic system Primary lymphoid tissue (bone marrow, thymus) Secondary lymphoid (spleen, mucosa- associated lymphoid tissue) From Medical Microbiology, 5 th ed. Murray, Rosenthal, and Pfaller. 2005
Background image of page 2
Elements of Host Protective Responses Compromised Barriers (e.g. skin) Quick host response (Innate responses e.g. phagocytosis, complement) Directed Attack (Adaptive response, e.g. T-cells) Microbial Attack Sound the Alarm (complement, chemokines)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Defnitions Nonspecifc and Specifc deFenses Innate Immunity: First line of defense (+) Always on (+) Rapid response (+) No need for previous exposure (nonspeciFc) (-) Can be overwhelmed (-) Lacks memory
Background image of page 4
Aquired Immunity: Second line of defense (-) Not “on” until exposed to foreign invader (speciFc) (-) Slow response—can take days to weeks to rise to full strength (+) Intense response (+) Protects better on second exposure Nonspecifc and Specifc DeFense Systems are connected The “Dark Side” oF the immune system Septic Shock Allergy or hypersensitivity; autoimmune disease Nonspecifc and Specifc deFenses
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Innate Immunity (nonspecifc)
Background image of page 6
Important features of epithelia: Tight junctions Basal lamina Basolateral and apical surfaces Goblet cells Mucus Reproduced from Bacterial Pathogenesis, A molecular approach 2 nd ed., Salyers and Whitt. 2002 Innate Immunity-Skin and Mucosal Surfaces
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Reproduced from Bacterial Pathogenesis, A molecular approach 2 nd ed., Salyers and Whitt. 2002 Innate Immunity-Skin and Mucosal Surfaces
Background image of page 8
Langerhans cell --Reside in epidermal layer --Type of dendritic cell --Sample for antigens for presentation --Key component of SALT (skin-associated lymphoid tissue) From Immunology, Infection, and Immunity. Pier, Lyczak, and Wetzler. 2004
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Reproduced from Bacterial Pathogenesis, A molecular approach 2 nd ed., Salyers and Whitt. 2002 Innate Immunity-Skin and Mucosal Surfaces
Background image of page 10
+ +++ Antibacterial peptides Bacterium Bacterium peptides Destruction of membrane Barrel-stave model
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
MALT (mucosa-associated lymphoid tissue) Antigen sampling across the intestinal barrier by M cells. Basolateral membrane of M cell contains a large pocket that is occupied by lymphocytes and macrophages. The lymphoid associated tissue of the gastrointestinal tract is GALT . Peyer ʼ s patches in the side of small intestine
Background image of page 12
Morphology and lineage of cells involved in immune response
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Innate Immunity (nonspecifc)
Background image of page 14
Phagocytic and Cytotoxic Cells: cellular effectors of innate immunity A . Phagocytic cells Moncycte Macrophage PMN (Polymorphonucelar neutrophil) Phagocytosis : ingestion of foreign particles by a cell Phagocyte :
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 16
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/25/2010 for the course PHYS 302L taught by Professor Tsoi during the Spring '10 term at University of Texas.

Page1 / 62

Lecture%202-Basic%20Concepts%20%28Immune%20system%29Slides...

This preview shows document pages 1 - 16. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online