GenCh14answers - Mutation, Repair, and Recombination 1. 2....

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Mutation, Repair, and Recombination 1. You need to know the reading frame of the possible message. 2. The mutant has a deletion of one base and this will result in a frameshift (–1) mutation. 3. Proline can be coded for by CCN (N stands for any nucleotide) and histidine can be coded for by CAU or CAC. For a mutation to change a proline codon to a histidine codon requires a transverion (C to A) at the middle position. Therefore, a transition-causing mutagen cannot cause this change. Serine can be coded for by UCN. A change from C to U at the first position (a transition) would cause this missense mutation and would be possible with this mutagen. 4. Assuming single base-pair substitutions, then CGG can be changed to CGU, CGA, CGG, or AGG and still would code for arginine. 5. a. and b. By transversion, CGG (arginine) can be become AGG (arginine), GGG (glycine), CCG (proline), CUG (leucine), CGC (arginine), or CGU (arginine). 6. The enol form of thymine forms three hydrogen bonds with guanine. 7. a. and b. After the first round of replication, the enol form of thymine will be paired with guanine. At the next round, the guanine will pair with cytosine to result in the TA•CG transiton. 8. a. Acridine orange causes frameshift mutations and frameshift mutations often result in null alleles. b. A +1 frameshift mutation can be reverted by two further single insertions so that the reading frame is re-established. 9.
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GenCh14answers - Mutation, Repair, and Recombination 1. 2....

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