Lecture - Vibrios - V I BRI OS a Over 20 species of Vibr...

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VI BRI OS Over 20 species of Vibr ios have been descr ibed, 12 are capable of causing human disease, 8 have been shown to be directly associated with food. Vibrio carchariae, V. damsela cause
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I NCI DENCE OF VI BRI OS Numerous studies have found that (30%) fresh, frozen and shrimp car r y Vibr ios. Others studies have revealed that a high percentage (100% and 67% respectively) of oysters and clams
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ymptoms: Septic shock Fatal in <24h Bullous lesions Wound infections Epidemiology: Raw oysters Liver disease or I ron overload Mouse + iron: LD50=1 bacter ia! V. vulnificus Disease
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Wound I nfections Normal M uscle tissue V. vulnificus wound
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Problems for Seafood About 50 cases/year even with public education Disease therapies not effective: 25 deaths/ year Post har vest oyster treatments not effective or not accepted
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Click to edit Master subtitle style Putative Vir ulence H emolysin: Lethal to mice But mutants still virulent Extracellular enzymes: proteases, phospholipase, DNases, etc. Pili I ron uptake: Siderophores, OMPs Lipopolysaccharide (LPS)
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CPS Phase Variation Less vir ulent Less CPS Virulent M ore CPS Translucent vs.
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Click to edit Master subtitle style V. Vulnificus Capsular Expressio Strains Phase Variation Virulence (LD 50 + Fe) Opaque Yes <10 2 Trasnslucent Yes 3 x 10 5 Mutant No 1 X10 7 Wright et al., 1990. I nfect. I mmun. Opaque Translucent Mutant
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EPI DEM I OLOGY The levels of most vibr ios in sur face waters and shellfish is seasonal and cor relates well with war m water temperature months (Apr il-October). Repor ted cases of most Vibrios illness are season
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Epidemiology Of all seafood consumed,
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Lecture - Vibrios - V I BRI OS a Over 20 species of Vibr...

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