ZOO4232 - Lecture 4 Amoebae

ZOO4232 - Lecture 4 Amoebae - 8/31/2010 Amoebae Phylum...

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8/31/2010 1 Amoebae • Phylum Sarcomastigophora • Sub-Phylum Sarcodina – Class Lobosea • Order Amoebida – Suborder Tubulina Genera: Entamoeba , Iodamoeba , Endolimax – Suborder Acanthopodina Genus: Acanthamoeba • Order Schizopyrenida Genus: Naegleria Entamoeba histolytica Trophozoite: 15-60um; nuclear karyosome (nucleolus) is central; fine peripheral chromatin Cyst: 12um; 1-4 nuclei; smooth chromatoidal bars. Facultative anaerobe Contain mitochondion-related organelle – mitosomes Genome size ~20MB; ~8201 predicted genes
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8/31/2010 2
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8/31/2010 3 Suborder Tubulina Size Host cells Main characteristic Entamoeba histolytica 25/12um Yes central nucleolus Entamoeba dispar Entamoeba hartmanni 12/6um No Entamoeba coli 25/17um No Coarse/eccentric nucleolus 8 nuclei Endolimax nana 9/9um No Iodamoeba buctschlii** 10/10um No glycogen vacuole in cyst Entamoeba gingivalis 15um No cyst stage Entamoeba polecki* 10um • *pigs; **pigs and primates E. coli E. histolytica E. polecki I butschlii E. bovis E. nana I. butschlii
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8/31/2010 4 Entamoeba coli
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8/31/2010 5 Entamoeba gingivalis No cyst stage Parasites reside in the large intestine
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8/31/2010 6 Epidemiology • Estimated yearly incidence world wide is 50,000,000 • Morbidity: 100,000/yr • Distribution: Worldwide (more pathogenic in tropics?). – Foci of infection/risk groups: Day care centers; Institutionalized populations; male homosexuals; travelers. • 44% annual prevalence in school children in Bangladesh; • Mode of transmission: Water; fecal-oral; food- borne. • Luminal amoebiasis (the carrier state) Disease presentation and pathogenesis
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8/31/2010 7 Intestinal Disease (Amebic Colitis) Gastro-intestinal pain, diarrhea, dysentery (blood in stool), weight loss • Recruitment of inflammatory cells to lesion • Invasion of colonic mucosa/lysis of mucosal epithelium. Thickening of mucosa
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ZOO4232 - Lecture 4 Amoebae - 8/31/2010 Amoebae Phylum...

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