ZOO4232 - Lecture 5 Intestinal and Urogenital Flagellates

ZOO4232 - Lecture 5 Intestinal and Urogenital Flagellates -...

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1 Intestinal and Urogenital Flagellates Phylum Sarcomastigophora • Subphylum Mastigophora (flagellates) • Class Zoomastigophorea – Order Retortamonadida – Genera: Chilomastix, Retortamonas – Order Diplomonadida • Suborder Diplomonadina – Genus: Giardia – Order Trichomonadida – Genera: Dientamoeba, Trichomonas. Pentatrichomonas Giardia lamblia = G. duodenalis= G. intestinalis • Parasite morphology • Trophozoite: – Size (14x12um) – adhesive disc – Microtubules and microfilaments – Two nuclei - central karyosome – Flagellar –4 pairs – Parabasal body – Median bodies? Division is longitudinal binary fission
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2 • Cysts are ovoidal Cysts are ovoidal. – flagellar retract, cytoplasm condenses – Thin but tough membrane forms cyst wall • Immature cysts have Immature cysts have two nuclei • Mature cysts have 4 nuclei
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3 Life Cycle Epidemiology • Giardia is most prevalent intestinal parasite. • Has world wide distribution. Common in children 6-10 years of age. Daycare centers Also prevalent in homosexual males. • travelers or visitors to endemic areas (immunity?). • Primary immuno-deficiency (IgA deficiency) Recent increase in Giardia infection among wilderness campers – Backpacker’s disease (may be acquired from contaminated water) Wild animals: Beavers; Dogs; sheep are also infected by Giardia
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4 Pathogenesis Incubation period - 1-2 weeks before onset of symptoms. It may take longer for cysts to appear in stool. May require 10 to 100 cysts to May require 10 to 100 cysts to establish infection (strain dependent). Prolonged duration of diarrhea Attachment of Giardia leads to shortening of villi of small intestine, inflammation of crypts of lamina propria and lesions on mucosa.
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ZOO4232 - Lecture 5 Intestinal and Urogenital Flagellates -...

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