PCB3134 - Lecture 6 Enzymes as Chemical Catalysts

PCB3134 - Lecture 6 Enzymes as Chemical Catalysts -...

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Biological Catalysts: Enzymes At end of 19th century, Justus von Liebig (organic chemist) Louis Pasteur (biologist) In 1897, Hans Buchner (bacteriologist) and Eduard (chemist) In 1926, James Sumner (Cornell University) In 1980s, Thomas Cech and Sydney Altman found some RNA molecules had catalytic properties. For clarity, “enzyme” is reserved for protein catalysts, “ribozyme” is used for RNA catalysts.
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The properties of enzymes Enzymes are proteins. Many are conjugated proteins with nonprotein components - cofactors may be inorganic (metals) or organic (coenzymes). Properties: Are required only in small amounts Are not altered irreversibly during course of reaction Have no effect on reaction thermodynamics
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Difference between enzymes and inorganic catalysts 1. More effective inorganic catalysts: a hundred to a thousand times enzymes: 108 to 1013 fold
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Difference between enzymes and inorganic catalysts 2. Under very mild temperature and pH conditions 3. Highly specific in reactants (substrates) they bind and the reaction they catalyze 4. Metabolic traffic directors 5. Activity can be regulated to meet particular cellular needs at particular time
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E A G G E A Transition state Activation Energy (EA)
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This note was uploaded on 09/25/2010 for the course PCB 3134 taught by Professor Multiple during the Fall '08 term at University of Florida.

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PCB3134 - Lecture 6 Enzymes as Chemical Catalysts -...

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