PCB3134 - Lecture 21 Cell to Cell Junctions and Plant Cell Walls

PCB3134 - Lecture 21 Cell to Cell Junctions and Plant Cell Walls

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Interactions of Cells with Other Cells We have talked about the components of ECM (Collagens, Elastins,    Proteoglycans, Fibronectins, and Laminins), the cell surface receptor    proteins Integrins, and the structures cell used to interact with ECM,    including Focal adhesions and Hemidesmosomes. Four families of integral proteins mediating cell-cell adhesion:    1. Selectins    2. Immunoglobulins    3. Integrins    4. Cadherins Several structures involved in cell-cell adhesion:    1. Adherens junctions    2. Desmosomes    3. Tight junctions    4. Gap juctions    5. Plasmodesmata Plant cell wall
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(Red) (Purple) Amphibian embryo Chick Evidence that cells associate with other cells of the same type
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Selectins A family of integral membrane glycoproteins:    1. A small cytoplasmic domain;    2. A single TM domain;    3. A large extracellular segment with a        lectin-like head. Selectins bind to a specific carbohydrate    head of an integral glycoprotein. The    binding requires calcium. L-selectin: leukocyte E-selectin: endothelial cells P-selectin: platelets and endothelial cells
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Yellow: key residues of selectin in binding Blue: the ligand Red: carbohydrate moieties crucial in binding
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A family of integral membrane proteins:    1. A small cytoplasmic domain;    2. A TM segment;    3. Several Fn domains;    4. Six Ig domains at the N-terminus. IgSF mediate Ca
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PCB3134 - Lecture 21 Cell to Cell Junctions and Plant Cell Walls

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