Ch1b09Lecture26

Ch1b09Lecture26 - Lecture 26 March 10, 2009 Summary of last...

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Summary of last lecture: •rubber elasticity •biopolymers: proteins Preview of coming attractions: •biopolymers •photosynthesis Lecture 26 March 10, 2009 Reminders •PS9 is optional, due Weds, 11:59 pm •Final review, Thursday 7:30 pm, Baxter •fill out TQFR on access.caltech after 3/16 1
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Final exam will be quasi-cumulative, but will emphasize material in lectures 16-26 •chemical equilibrium •kinetics •organic chemistry and reaction mechanisms •polymers and biopolymers •material from the entire course may be incorporated into problems review session Thursday, 7:30 pm Baxter Hall can e-mail questions in advance 2 same policies as midterm/Quiz
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Pauling s vision of α -helix/ β -sheet packing; the mechanism of muscle contraction and the interconversion between helices and sheets 3 Biopolymers I: proteins Parsons, sect 11.3
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Protein Folding (denatured, unfolded) (native, folded) D N Anfinsen s thermodynamic hypothesis: N is the state of lowest free energy Anfinsen Nobel Lecture (1972) 3a
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mechanism of protein folding: D N Vijay Pande, Stanford folding@home villin 36 residues Zagrovic et al JMB 323 927 (2002) trajectory 10+ μs hydrophobic collapse ~ 20 ns 3b
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foldit - “an online game in which humans try to solve one of the hardest computational problems in biology: protein folding” http://fold.it/portal/
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Biopolymers II: nucleic acids N N N N NH 2 O H O H H H H P O O - O O - N NH 2 O N O H O H H H H P O O O - NH N N O NH 2 N O H H H H H O P O O O - NH O O N O H O H H H H P O HO O - thymine = base guanine cytosine adenine 2-deoxyribose 3 -5 phospho- diester linkage 5 3 1 5 3 DNA = deoxyribonucleic acid RNA utilizes ribose (with 2-OH) and uracil (instead of T) 4 Parsons, sect 11.4
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Watson-Crick base-pairing in DNA A G C T 6
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Biopolymers III: polysaccharides extensive hydrogen-bonding between chains renders cellulose virtually insoluble in most solvents http://www.lsbu.ac.uk/water/hycel.html “The cellulosic approach can pull energy out of nearly any plant material, but the process is difficult because it must draw sugars from tough substances inside plants” E. Douglass, LA Times Business Section, March 8, 2007 O H O H HO H H OH H
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This note was uploaded on 09/25/2010 for the course CH 104 taught by Professor Bopanna during the Fall '09 term at UMBC.

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Ch1b09Lecture26 - Lecture 26 March 10, 2009 Summary of last...

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