Lecture_20_Set_Points - ENERGY BALANCE Weight = Energyin -...

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ENERGY BALANCE Weight - Energy out = Energy in Weird Al Yankovic – Grapefruit Diet
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Gordon Kennedy
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0 5 10 15 20 25 30 35 40 1234567891 0 Time (days) Food Intake (g) Hypothalmic Hyperphagia 200 220 240 260 280 300 320 340 Body Weight (g)
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0 5 10 15 20 25 30 35 40 1234567891 0 Time (days) Food Intake (g) Hypothalmic Hyperphagia 200 220 240 260 280 300 320 340 Body Weight (g) lesion
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0 5 10 15 20 25 30 35 40 1 3 5 7 9 11 13 17 19 Time (days) Food Intake (g) Hypothalmic Hyperphagia 200 220 240 260 280 300 320 340 Body Weight (g) lesion
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0 5 10 15 20 25 30 35 40 1 3 5 7 9 11 13 17 19 Time (days) Food Intake (g) Hypothalmic Hyperphagia 200 220 240 260 280 300 320 340 Body Weight (g) lesion
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VMH Lesions
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0 5 10 15 20 25 30 35 40 1 4 7 13 16 19 22 28 31 34 37 Time (days) Food Intake (g) 200 220 240 260 280 300 320 340 360 Body W eight (g) lesion Kennedy’s Contribution
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0 5 10 15 20 25 30 35 40 1 6 11 16 21 26 31 36 41 46 Time (days) Food Intake (g) Hypothalmic Hyperphagia 200 220 240 260 280 300 320 340 360 Body Weight (g) lesion
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0 5 10 15 20 25 30 35 40 1 6 11 16 21 26 31 36 41 46 51 56 Time (days) Food Intake (g) Hypothalmic Hyperphagia 200 220 240 260 280 300 320 340 360 Body Weight (g) lesion
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Gordon Kennedy feeding center regulation of body fat
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Critical Component of Set-Point Theory Adipose Cell hypothalamus ? Genetic Memory $
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Kennedy’s Contribution 1.No feeding or satiety centers in brain 2.Body weight (fat) is regulated 3.Eating behavior is controlled by physiological mechanisms involved in the regulation of body weight.
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Critical Component of Set-Point Theory Adipose Cell hypothalamus $
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LEPTIN 1994 - Zhang, Proenca, Maffei, Baronne, Leopold, Friedman.
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Evidence supporting leptin Two strains of obese mice were deficient in leptin (Zhang et al, 2004) Overeat Low metabolic rate Inject leptin into these obese mice (Halaas et al, 1995), Campfield et al, 1995) Stop eating Increase in metabolic rate Weight normalizes Leptin produced by adipose cells (Zhang et al, 2004) Serum leptin concentrations proportional to fat composition. (Hardie
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Lecture_20_Set_Points - ENERGY BALANCE Weight = Energyin -...

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