Signs and symptoms

Signs and symptoms - Genes regulating apoptosis 9/28/10...

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9/28/10 Genetics studies on New Zealand mice having SLE revealed that: -Developing autoimmunity is the effect of several mutatn genes. p Most extensively studied gene: lpr Genes regulating apoptosis
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9/28/10 What is lpr gene? lpr located on the chromosome 19. After mutation…. . Causing defecs in the Fas antigen by inserting an endogenous retrovirus in the Fas gene. Genes regulating apoptosis Involved in transduction of apoptotic signals
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9/28/10 In normal situation…. Thymocytes ( T cell precursors which develop in the thymus) with CD4+CD8+ are selected. CD4+CD8+ thymocytes have functional T-cell receptors expressed. Thymocytes with CD4-CD8- CD4+CD8- CD4-CD8+ undergoes apoptosis. Q Q Genes regulating apoptosis
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9/28/10 Genes regulating apoptosis
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9/28/10 In SLE patients…. {24AC 98F-C6CD-497 -BE42-A2EA3E61D6A2} {B1521FA7-E A3-4B5C-A B9-7A56940BC751} tional Fas protein in thymocyte. {D1B6808C-F 8B-4 CB-9B56-DE0DF4F3FDEF} Failure of thymic selection {A4CFAD1E-17DD-489B-A35F-9B8EA8FA4280} Extension of the lifespan of malfun
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This note was uploaded on 09/26/2010 for the course BIO BIO2110 taught by Professor Kwam during the Spring '10 term at 한동대학교.

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Signs and symptoms - Genes regulating apoptosis 9/28/10...

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