Lecture 6 Memory Mechanisms

Lecture 6 Memory Mechanisms - 2 OBJECTS, ONE REPLACEMENT...

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Chapter 8 Lecture 6 Memory Mechanisms
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Figure 8-26
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Figure 8-25 - Overview
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Figure 8-27a - Overview Postsynaptic Summation
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Figure 8-28 - Overview Spatial or Temporal Summation
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Figure 8-28a
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Figure 8-28b
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Figure 8-27b - Overview Postsynaptic Inhibition
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Figure 8-29a - Overview
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GLUTAMATE GLUTAMATE MEMBRANE K + Na + Ca ++ Mg ++ NMDA Receptors
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GLUTAMATE RECEPTORS: AMPA AND NMDA Two Glutamate Receptors: AMPA and NMDA
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Figure 8-30 - Overview NMDA Receptor - Memory Mechanism 1. Increase in glutamate release 2. Increase in AMPA receptors
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NMDA RECEPTORS AND MEMORY NR 1 NR 1 NR 2 NR 2 NMDA RECEPTOR CONSISTS OF NR1 & NR2 SUBNUNTS JUVENILE ADULT NR 1 NR 1 NR 2B NR 2B NR 1 NR 1 NR 2A NR 2A EPSP EPSP NR2B MUTANT ADULTS: LTP = ENHANCED LTD = NO CHANGE PAIRED PULSE FACILITATION = NO CHANGE NOVEL OBJECT RETENTION IN MICE:
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Unformatted text preview: 2 OBJECTS, ONE REPLACEMENT MUTANT NR2B MICE SHOW BETTER RETENTION AFTER 24 HOURS NMDA Receptors can influence memory in mice GILL WITHDRAWAL MOTOR NEURON SIPHON SENSORY NEURON HEAD FACILITATORY NEURON TIME R E S P O N S E PRESYNAPTIC DECREASE IN CALCIUM CHANNEL ACTIVITY STIMULUS HABITUATION Ca ++ APLYSIA M O T O R N E U R O N Habituation GILL WITHDRAWAL MOTOR NEURON SIPHON SENSORY NEURON HEAD FACILITATORY NEURON R E S P O N S E PRESYNAPTIC DECREASE IN POTASSIUM CHANNEL ACTIVITY STIMULUS SENSITIZATION Ca ++ K + PROLONGED PRESYNAPTIC DEPOLARIZATION AND MORE CALCIUM INFLUX APLYSIA Sensitization M O T O R N E U R O N...
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This note was uploaded on 09/27/2010 for the course PGY 166214 taught by Professor Hudson during the Fall '10 term at SUNY Buffalo.

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Lecture 6 Memory Mechanisms - 2 OBJECTS, ONE REPLACEMENT...

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