Immunity Review

Immunity Review - Introduction to Immunity Defends against...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Introduction to Immunity… Defends against infection by viruses, bacteria, fungi, and parasites; works to destroy and recycle worn out cells, identifies and destroys cancer cells When it doesn’t work: allergies, autoimmune disease, immunodeficiency diseases, limits tissue/organ transplants Types of immunity: innate (nonspecific), acquired (specific) Lymphatic System Lymph- excess fluid that leaves through capillaries, drains into blind-ended lymphatic capillaries, collects into lymphatic vessels, then lymph veins which converge on lymph nodes o Drains into lymphatic ducts, which drain into the thoracic duct where lymph drains back into the blood Lymph nodes have physical barriers that filter foreign bacteria, cellular debris o Home to vast numbers of cells of the immune system (lymphocytes, macrophages, etc.) o Possible threats are brought to the immune system, which is conducting surveillance by way of the lymph nodes Red bone marrow is included in the lymphatic system o T lymphocytes are born in the bone marrow and mature in the thymus, B lymphocytes are born and mature in the bone marrow Spleen has vessels where the blood pools, effector cells of the immune system residing there conduct surveillance of RBCs, picking out damaged cells and destroying them. Red bone marrow also reproduces RBCs Typical response to hemorrhage: vasoconstriction of leg veins puts blood back into circulation to help build up BP and blood volume, and constriction of smooth muscle in the spleen squeezes blood up Overview of Innate Immunity (Nonspecific) Inherited, rapidly acting, requires no activation, no memory of prior exposure Includes barrier, chemical, and cellular defenses Barrier Defenses Skin- stratified (flat) epithelium Stratum corneum is impervious (cellular outer layer)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
o Give rise to new skin cells, which are pushed to the surface, by the time the cells go to the outside, they are dead, filled with keratin protein to protect skin from infiltration (impervious to water loss, organisms, insulating properties) Secretions of the skin, which include sweat and oil glands, are pretty inhospitable (secreted via ducts) o Oil and sweat glands, pH 3-5, acidic environment is inhospitable for pathogenic organisms o Some organisms have adapted, some can live peacefully cohabitating Epidermis (skin Mucus o Surfaces exposed to environment are lined with mucus o Sticky to trap foreign matter and prevent them from penetrating cells underneath o Contains antibodies, proteins, can be moved by cilia Normal flora- specialized symbiotic bacteria that are part of innate immune defenses
Background image of page 2
Innate Cellular Defenses White Blood Cells: Cells of innate cellular defense recognize markers innate to bacteria In blood o Neutrophils- phagocytes, ingest bacteria through phagocytosis, have receptors that bind to molecules on the surface of bacteria, common to most bacteria o Monocytes (macrophages)- phagocytes, ingest bacteria
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/28/2010 for the course BISC 220 taught by Professor Mcclure during the Spring '09 term at USC.

Page1 / 9

Immunity Review - Introduction to Immunity Defends against...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online