10 LECTURE 2 BIO 325

10 LECTURE 2 BIO 325 - Wolpert 3.2 Overview of development...

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Unformatted text preview: Wolpert 3.2 Overview of development Xenopus ZebraFsh Chick Mouse Gametogenesis and ertilization Cleavage Gastrulation Organogenesis Organ maturation Axis speciFcation Meiotic prophase I Meiotic metaphase I Meiotic anaphase I Gilbert 19.22 Secondary oocyte Zona pellucida Polar body Primary oocyte DNA Spindle Oogenesis completion of meiosis I triggered by ovulation Meiotic prophase I Meiotic metaphase I Meiotic anaphase I Gilbert 19.22 Secondary oocyte Zona pellucida Polar body Primary oocyte DNA Spindle Oogenesis completion of meiosis I triggered by ovulation Meiotic Metaphase II Aneuploidy leading cause of miscarriage, congenital defects and mental retardation 10-25% of fertilized human oocytes are aneuploid Risk factors include: Suggested that environmental pollutants/pesticides maternal age, irradiation, smoking or drinking, oral contraceptives and fertility drugs Antigen 1 st Antibody -tubulin 2 nd Antibody Fluorescent tag -tubulin DNA stained with 4 ,6 diamidino-2-phenylindole Immunostaining * Confocal Imaging Congression MII Congression Failure Slack 5.7 99.5% 0.5% Visualization of events preceding aneuploidy Congression MII Congression Failure 99.5% 0.5% Unexplained increase in Congression Failure 94% 6% After August 1998 Before August 1998 Bisphenol A (BPA)...
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This note was uploaded on 09/29/2010 for the course BIO 325 taught by Professor Bernadette-holdener,g during the Fall '08 term at SUNY Stony Brook.

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10 LECTURE 2 BIO 325 - Wolpert 3.2 Overview of development...

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