Lecture 12 - Lecture 12 Motor Proteins Types...

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Lecture 12 Motor Proteins Types (substrate-motor) Linear: Microtubules (tubulin) – dynein (+ to -), kinesin (- to +) DNA – helicases Microfilaments (actin) – myosin Rotary: Bacterial flagella F 0 F 1 ATP synthases Motion depends on flexible 3 o structure Reversible binding ATP hydrolysis affecting binding Microtubule -- kinesin Microtubule: right-handed hollow helix of tubulin α / ß dimers + ß α - Kinesin: left-handed helix with two globular heads
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(hydrolysis ) (exchange) (loose) (tight) H2O Pi ATP ADP ADP ATP ATP ADP ATP ADP ATP Rotation Rotation Actin-myosin Microfilaments: right-handed double helix of actin monomers G-actin ionic strength F-actin high low Myosin (Fig. 16.5) Left-handed coiled-( α -helix) coil: heavy chain NH 2 heavy chain COOH light chains (Fig. 16.9) H 2 O +ATP -ADP -Pi High-stress Myosin-actin Low-stress conformation connection form
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Lecture 12 - Lecture 12 Motor Proteins Types...

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