Pain and Anesthetics

Pain and Anesthetics - pain ANESTHETICS NOTHING BEGINS, AND...

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1 1 “NOTHING BEGINS, AND NOTHING ENDS THAT IS NOT PAID WITH MOAN; FOR WE ARE BORN IN OTHER’S PAIN, AND PERISH IN OUR OWN.” Francis Thompson 1859 -1907 pain ANESTHETICS 2 PAIN Pain has an element of blank; It cannot recollect When it began, or if there was A time when it was not. It has no future but itself, Its infinite realms contain Its past, enlightened to perceive New periods of pain. Emily Dickinson 3 4 There is no device to measure pain. Pain is what the person says it is. The more the pain-the longer it takes to recover.
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2 5 “Think of pain as a disease” The spinal cord “rewires” itself when there is pain- pain can become “permanent”. Many hospitals have a 10 point pain scale. 6 Balshine’s lebensweicker 7 opium MORPHINE MORPHEUS 8 trephination
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3 9 10 Raymundus Lullius Spain - 1275 sweet vitriol H 2 SO 4 11 Ether? born: 10 November 1493 Paracelsus 12 CH 3 -CH 2 -O-H heat, acid
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4 13 CH 3 CH 2 -O-CH 2 CH 3 “ether” 14 Joseph Priestley 1772 N 2 O Sir Humphrey Davy - early 1800s N + N O - 15 16 Late 1800s
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5 17 Crawford Williamson Long 1842 ether 2 tumours removed 18 Horace Wells 1844 ether 19 William T. G. Morton 1846 used ether He called it Letheon 20 John Collins Warren - 1846
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6 21 I did not experience pain at any time, though I knew that the operation was proceeding. Edward Gilbert Abbott Gentlemen, this is no humbug! 22 Massachusetts General Hospital 23 24
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7 25 Robert Houdin 26 JAMES SIMPSON CHLOROFORM 1847 27 And the Lord caused a deep sleep to fall upon Adam and he slept.-and He took one of his ribs and closed up the flesh .” Genesis 2:21 Childbirth Issue 1853 Queen Victoria was anesthetized - 8 th child. 28
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8 29 Dr. Harold Randall Griffith Introduced muscle relaxants Curare (Intocostrin) “before and after Griffiths” Modern Times 30 31 PREANESTHETIC MEDICATION Block secretions (Atropine) Narcotics (Demerol) Sedatives (Valium, Barbiturates) INTRAVENOUS ANESTHETICS Thiopental sodium Fentanyl 32 Potency ½ Life(hr) Morphine 1 2 Fentanyl 100 5 GASEOUS ANESTHETICS Nitrous oxide Halothane Enflurane
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9 33 General anesthesia is defined by reversible unconsciousness and lack of response to noxious stimuli induced by chemical agents. Mechanisms underlying the anesthetic effect are
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This note was uploaded on 09/29/2010 for the course SCIENCE 183 taught by Professor Harpp during the Spring '10 term at McGill.

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Pain and Anesthetics - pain ANESTHETICS NOTHING BEGINS, AND...

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