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Lect15 - Lecture 15 Glycogen synthesis 1 Glycogen Synthesis...

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1 Lecture 15 Glycogen synthesis
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2 Glycogen Synthesis: Thermodynamically Unfavorable Glycogen Breakdown Principle: Breakdown and synthesis have key steps that are different
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3 Phosphoglucomutase Reversible reaction
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4 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate From phosphoglucomutase UDP-sugars used frequently, as in glycosylation of proteins
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5 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate through a coupled reaction From phosphoglucomutase Coupled Reactions
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6 Coupled Reactions Coupling UDP-glucose pyrophosphorylase to inorganic pyrophosphatase
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7 Glycogen Synthesis
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8 Glycogen Synthase UDP-Glucose + Glycogen n UDP + Glycogen n+1 Glycogen Synthase UDP good leaving group Attachment to C4-OH of nonreducing end, forming an (1 >4) glycosidic bond. • Regulated (more on this later …)
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9 UDP good leaving group - activation of glucose 4 1 4
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10 Glycogen granules: How do you start?
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