Lect15 - 1 Lecture 15 Glycogen synthesis 2 Glycogen...

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Unformatted text preview: 1 Lecture 15 Glycogen synthesis 2 Glycogen Synthesis: Thermodynamically Unfavorable Glycogen Breakdown Principle: Breakdown and synthesis have key steps that are different 3 Phosphoglucomutase • Reversible reaction 4 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate From phosphoglucomutase UDP-sugars used frequently, as in glycosylation of proteins 5 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate through a coupled reaction From phosphoglucomutase Coupled Reactions 6 Coupled Reactions Coupling UDP-glucose pyrophosphorylase to inorganic pyrophosphatase 7 Glycogen Synthesis 8 Glycogen Synthase UDP-Glucose + Glycogen n UDP + Glycogen n+1 Glycogen Synthase • UDP good leaving group • Attachment to C4-OH of nonreducing end, forming an (1 — >4) glycosidic bond. • Regulated (more on this later …) 9 UDP good leaving group - activation of glucose 4 1 4 10 Glycogen granules: How do you start?...
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This note was uploaded on 09/29/2010 for the course ECON 100A taught by Professor Smith during the Spring '08 term at Alabama.

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Lect15 - 1 Lecture 15 Glycogen synthesis 2 Glycogen...

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