Lect17 - Ketone Bodies Liver mitochondria, Acetyl-CoA...

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Unformatted text preview: Ketone Bodies Liver mitochondria, Acetyl-CoA converted to: Metabolic fuel for heart and skeletal muscle During starvation, also feeds the brain 1 Reverse of last step of !-oxidation 2 Acetyl- CoA (1 recycled) A third Acetyl-CoA HMG-CoA precursor for cholesterol Acetoacetate Ketone bodies: Way to transport Acetyl-CoA from mitochondria in the liver to other tissues 2 + CO 2 Ketosis: Other ketone bodies (in other tissues) Slow, spontaneous 3 Key intermediate Liver supplies ketone bodies Acetoacetate: Respiration Heart muscle Renal cortex 3-hydroxybutyrate Respiration Brain cells use ketone bodies during fasting or diabetes Low [oxeloacetate] 4 How are ketone bodies used? Ketone bodies are a way to store Acetyl-CoA Thiolase: last step of !-oxidation Donor of CoA is succinyl-CoA 3-ketoacyl-CoA transferase is not present in liver 5 When insulin is absent 6 Lecture 17 Fatty Acid Metabolism (II) 7 http://www.genome.jp/kegg/pathway/map/map01100.html Citric acid cycle Glycolysis/ Gluconeogenesis Oxidative phosphorylation Carbon fixation Glycan metabolism Fatty acid metabolism Pentose Phosphate metabolism Fatty acid synthesis Fatty Acid Biosynthesis: Condensation of C2 units Konrad Bloch 1912-2000 Nobel Prize in Physiology or Medicine, 1964 David Rittenberg 1906-1970 9 Types of Fatty Acids Even carbon Odd carbon Branched Ether Halogenated Ladderane 11 Fatty Acid Synthase Malonyl transacylase !-ketoacyl synthase (condensation) Dehydrase Enoyl Reductase !-ketoacyl reductase Thioesterase Dimer is active Monomer is not 12 Catabolism and Anabolism Differ Acyl Carrier Protein 13 Acetyl-CoA...
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Lect17 - Ketone Bodies Liver mitochondria, Acetyl-CoA...

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