MCB 32 Lecure 4 - Molecular Cell Biology 32 Professor Terry...

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Molecular Cell Biology 32 Professor Terry Machen 9/7/10 Lecture 4 ASUC Lecture Notes Online is the only authorized note-taking service at UC Berkeley. Do not share, copy, or illegally distribute (electronically or otherwise) these notes. Our student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. Announcements Dr. Lew will be lecturing Thursday because I will be gone. I will post videos on bSpace that show the whole scheme of ETC, Glycolysis, and the Krebs cycle. Lecture Today we will be discussing Diffusion, permeability-hydrophobic, ions and membrane voltage, and permeability. This will introduce the discussion of nerve cells, which basically operate using electricity. When you step on a pin, you withdraw within a fraction of a second. During this time, an impulse is sent to the brain and back via the nerves to generate a reflex, which allows you to withdraw your foot. We will start with diffusion, which is how this mechanism works. First, however, a video from last lecture: This video shows the relationship between the three cycles. NADH and FADH2 give up electrons to the electron transport chain. Electrons are given to proteins that reside in the mitochondrion inner membrane. The proteins use the energy from the NADH and FADH2 electrons to pump hydrogens into the intermembrane space. The hydrogen is then sent back in the matrix of the mitochondrion, which rotates a motor known as ATP synthase. This produces a large amount of ATP per glucose molecule. Glycolysis and Krebs cycle produce a small amount of ATP, but are really used to produce NADH and FADH2 for the electron transport chain. ATP synthase works as a turbine to use the flow of protons which go through the system’s entry chamber. As the synthase rotates, it uses the energy of the proton gradient and converts it to rotational energy, which is used to catalyze the formation of ATP from ADP and inorganic phosphate. Molecular structure animation shows that the central shaft of the ATP synthase is the part that rotates. Like all enzymes, ATP synthase can also work in the opposite direction, by breaking ATP into ADP and Pi. You don’t need to remember the details; just that ATP synthase makes ATP. Diffusion refers to the random mixing of molecules,
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This note was uploaded on 09/29/2010 for the course MCB 57703 taught by Professor Machen during the Fall '08 term at University of California, Berkeley.

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MCB 32 Lecure 4 - Molecular Cell Biology 32 Professor Terry...

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